How long does tramadol stay in your system?

Gail Evans, Alphabiolabs

By Gail Evans, Technical Trainer at AlphaBiolabs
Last reviewed: 29/01/2025

How long tramadol stays in your system depends on several factors including how the drug is ingested, how often it is used, and the metabolism and weight of the individual.

In this article, we look at how long tramadol stays in your system, including how long it remains detectable in drug tests. We also look at some of the side effects and risks of tramadol use.

What is tramadol?

Tramadol – also known as Tramal or Ultram – belongs to a group of drugs called opioid analgesics, and is a powerful painkiller used in medical settings to treat moderate to severe pain. It can also be prescribed to treat long-term pain, where other painkillers are no longer effective.

While not as powerful as other opioids, like heroin, its effects are similar, and both substances can be addictive. Taking tramadol can make you feel calm, happy, and relaxed, and relieve symptoms of pain. However, it can also make you feel tired and lethargic, moody, irritable, and confused.

When legally prescribed, a doctor or other medical practitioner will carefully manage the prescription, to minimise the risks of long-term addiction.

What happens in the body when you take drugs?

When a person consumes drugs, they are broken down by the liver, and a proportion of the drug and its metabolites are released into the bloodstream.

Some of the drug and its metabolites can then be detected in the body in different ways including via sweat, urine, saliva, hair and nails.

In the case of hair and nails, a proportion of the drug and its metabolites travel to the blood vessels in the hair follicles and nail bed.

Substances then become trapped in the hair shaft (cortex) and the keratin fibres of the nails, remaining in hair and nails as they grow, and making it possible to determine whether someone has consumed drugs, using hair and/or nail testing.

What does tramadol do to you?

Tramadol is a prescription pain relief medication that works by binding to opioid receptors in the brain, reducing the perception of pain and sometimes causing feelings of relaxation or mild euphoria.

Is tramadol the same as Zapain?

No, tramadol and Zapain are not the same. The main difference between the two drugs is their composition: tramadol is a single-drug opioid painkiller, while Zapain is a pain reliever made up of codeine (an opioid) and paracetamol (acetaminophen).

Because codeine is less potent than tramadol, Zapain is more suitable for mild to moderate pain and is commonly used for short-term relief (e.g. for injuries or following dental procedures).

Tramadol is often prescribed for moderate or severe chronic pain and presents a greater risk for addiction and dependency.

How long does tramadol stay in your system?

How long tramadol remains in the system can depend on several factors including how the drug is ingested, how often it is used, the dosage, and the metabolism and weight of the individual.

Even after the effects of the drug have worn off, and long after the drug was first consumed, tramadol can be detected by a drug test, depending on the type of test you take.

The drug testing detection windows for tramadol are as follows:

  • Oral fluid (saliva) – up to approximately 48 hours
  • Urine – up to approximately 4 days
  • Hair – up to 12 months (depending on the length of hair available)
  • Nails – up to 12 months (up to 6 months for fingernails and up to 12 months for toenails)

Oral fluid and urine drug testing are known as ‘narrow-window’ forms of testing and can be used to detect drug use from 30 minutes after consumption, up to a few days. This can vary depending on the type of substance and how much was used.

The rate at which hair and nails grow means that both hair drug testing and nail drug testing can provide a ‘wide-window’ of detection for drugs and their metabolites (up to 12 months).

What factors affect how long tramadol stays in your system?

Factors that affect how long tramadol stays in your system include:

  • Quantities taken
  • Frequency of use
  • Metabolism and weight
  • Formulation of the drug (e.g. slow-release tramadol pills/tablets remain in your system for longer)

Is tramadol addictive?

Tramadol can be addictive, although it is often perceived as less addictive than stronger opioids like morphine and oxycodone.

Tramadol binds to opioid receptors in the brain, providing pain relief and feelings of euphoria, which can lead to addiction in some people who use it.

Repeated use can also cause the body to develop a tolerance, meaning that higher doses are required to achieve the same effect. Physical dependence can also occur, leading to withdrawal symptoms when tramadol use is reduced or stopped.

What are the long-term effects of tramadol use?

The long-term physical effects of tramadol misuse/abuse can include:

  • Physical dependence, tolerance and addiction
  • Constipation
  • Liver and kidney damage
  • Cardiovascular problems
  • Weakened immune system
  • Hormonal imbalances
  • Increased risk of depression or anxiety

People who misuse tramadol over a long period of time may also experience withdrawal symptoms when they reduce their intake or stop using it.

Does tramadol show up on a drug test?

Yes, tramadol can show up in drug tests including urine, oral fluid (saliva), hair and nail drug tests.

Urine drug tests and oral fluid drug tests provide a narrow window of detection, meaning that they can only tell us whether an individual has been using drugs in the few days prior to the samples being collected.

A urine drug test provides a window of detection up to approximately four days. An oral fluid (saliva) drug test provides a window of detection up to approximately 48 hours.

This makes urine and especially oral fluid drug tests ideal for circumstances where an individual is suspected to be under the influence of drugs in the ‘here and now’, or for day-to-day monitoring of drug use.

Hair drug tests and nail drug tests provide us with a wide window of detection (up to 12 months). This is due to the way in which drugs are retained in the hair and nails, long after substances were first consumed.

Hair drug tests can be used to identify a month-by-month pattern or an overview of drug use (segmented or overview analysis) for up to 12 months. Nail drug tests are ideal where hair testing is not possible, providing an overview of historic drug use up to six months (fingernails) or up to 12 months (toenails).

How long does it take for tramadol to show up on a drug test?

Even after the effects of the drug have worn off, tramadol use can still be detected by a drug test, depending on the type of test you take.

The drug testing detection windows for tramadol are as follows:

  • Oral fluid (saliva) – up to approximately 48 hours
  • Urine – up to approximately 4 days
  • Hair – up to 12 months (depending on the length of hair available)
  • Nails – up to 12 months (up to 6 months for fingernails and up to 12 months for toenails)

Oral fluid and urine drug testing are known as ‘narrow-window’ forms of testing and can be used to detect drug use from 30 minutes after consumption, up to a few days. This can vary depending on the type of substance and how much was used.

The rate at which hair and nails grow means that both hair drug testing and nail drug testing can provide a ‘wide-window’ of detection for drugs and their metabolites (up to 12 months).

Where can I get drug testing for tramadol?

Our laboratory can test for a wide range of drugs and their metabolites (breakdown products), including tramadol, using a variety of samples (hair, nails, urine and oral fluid).

With over 20 years’ experience offering drug testing for peace of mind, official matters, the legal sector and the workplace sector, we provide a variety of drug testing services to suit a range of needs, including:

For more information or to request a quote call our Customer Services team on 01 402 9466 or email info@alphabiolabs.ie.

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Gail Evans, AlphaBiolabs

Gail Evans

Technical Trainer at AlphaBiolabs

A professionally-trained forensic scientist, Gail joined AlphaBiolabs in 2012 and holds the role of Technical Trainer.

Her day-to-day responsibilities include delivering in-depth training sessions both internally and externally, covering DNA, drug, and alcohol testing.

Throughout her career at AlphaBiolabs, Gail has held a variety of roles, including within the Legal and Workplace sectors of the business.

Before joining the company, Gail was a practicing forensic scientist with 25 years’ experience working for the Forensic Science Service, attending scenes of crime, and analysing physical and biological material with potential evidential value.

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